Polyclonal Anti-PSA Is More Sensitive but Less Specific Than Monoclonal Anti-PSA
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منابع مشابه
Anti-Prostate Specific Antigen (Anti-PSA) Modified Interdigitated Microelectrode-Based Impedimetric Biosensor for PSA Detection
Interdigitated microelectrodes (IDEs) functionalized with a cysteamine (Cys) self-assembled monolayer (SAM) were used to fabricate a sensitive, disposable, impedimetric biosensor for prostate specific antigen (PSA) detection. PSA specific monoclonal antibody (anti-PSA) was covalently immobilized on cysteamine modified gold surface of IDEs, using N-ethyl-N’-(3-dimethylaminopropyl) carbodiimide a...
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Background & Aims: Nanostructure materials have recently been considered to be investigated due to their specific properties in biology, medicine, and forensic sciences. Violence against women who are assaulted is of great significance in a forensic medicine and semen detection (with or without spermatozoon) is very important in this field. The presence of PSA in vagina is an indicator of...
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background: we aimed to value the usefulness of free to total prostate-specific antigen and prostate-specific antigen (psa) density for prostate cancer in the patients with psa levels of 4.0 ng/ml or less. methods: a total of 343 subjects with psa levels of 4.0 ng/ml or less were biopsied. all patients were divided into four groups according to the psa levels: 0 to 1.0 ng/ml, 1.1 to 2.0 ng/ml, ...
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Objective(s): Prostate cancer is the world’s leading cause of cancer and the second cause of cancer-related death in men after lung cancer. Differentiation of prostate adenocarcinoma from benign prostate lesions and hyperplasia sometimes cannot be done on the basis of morphologic findings. Considering the fact that in the prostate adenocarcinoma there is no basal cell layer, basal cell markers ...
متن کاملProduction and characterization of novel anti-prostate-specific antigen (PSA) monoclonal antibodies that do not detect internally cleaved Lys145-Lys146 inactive PSA.
BACKGROUND The nature of free, uncomplexed prostate-specific antigen (PSA) in the circulation is still unknown. In this study, we developed novel anti-PSA antibodies using PSA produced by a metastasized cancer cell line, LNCaP, as an immunogen. METHODS Hybridoma cell lines were screened with different methods that aimed at finding antibodies specific for the forms of free PSA produced by LNCa...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2002
ISSN: 0002-9173,1943-7722
DOI: 10.1309/bgwq-p26t-7tr6-vgt3